{"campaign":{"id":"LPAR1_ECL2_DEMO","name":"LPAR1 ECL2 Campaign","target":"LPAR1","template":"7TD0","ecl2Range":"188-211","hotspots":["R190","Y194","D198","K201","F205"],"candidateCount":10},"stages":[{"name":"Boot GPU VM","description":"Start the A100 worker VM, attach the LPAR1 campaign inputs, and keep the run record tied to the cloud job.","state":"running"},{"name":"Run drug design model","description":"Execute RFantibody/RFdiffusion on the GPU VM to generate ECL2-focused VHH candidates and output artifacts.","state":"running"},{"name":"Run evaluation model","description":"Filter and gate generated candidates with Boltz-2 ipSAE, epitope contacts, ipTM, pTM, VHH developability checks, and structure artifacts before ranking returned results.","state":"ready"}],"rankedCandidates":[{"rank":1,"id":"LPAR1_NB_002","interfaceScore":0.863,"specificityMargin":0.4,"developabilityScore":0.842,"rankScore":0.7017},{"rank":2,"id":"LPAR1_NB_001","interfaceScore":0.817,"specificityMargin":0.363,"developabilityScore":0.767,"rankScore":0.649},{"rank":3,"id":"LPAR1_NB_003","interfaceScore":0.792,"specificityMargin":0.311,"developabilityScore":0.751,"rankScore":0.618}],"run":{"runId":"local-seeded-demo","startedAt":"2026-09-25T09:35:16.197Z","updatedAt":"2026-09-25T09:35:24.200Z","currentStage":"final candidates returned","validationStatus":"passed","retryCount":1,"outputUri":"local://.gpcrclaw/artifacts/campaigns/local/local-seeded-demo/reports/campaign_report.json","stages":[{"id":"inputs","label":"Inputs","status":"done","detail":"LPAR1 target, 7TD0 template, ECL2 residues, hotspot constraints"},{"id":"generation","label":"Generation","status":"done","detail":"Generate VHH candidates against the compiled ECL2 design brief"},{"id":"validation","label":"Validation","status":"done","detail":"Filter with Boltz-2 ipSAE, epitope contacts, ipTM, pTM, VHH sequence gates, and required artifacts"},{"id":"retry","label":"Retry/regenerate","status":"done","detail":"Regenerate the failed candidate and carry forward the retry count"},{"id":"final","label":"Final returned candidates","status":"done","detail":"Return ranked candidates with output URI and research boundary"}],"generatedCandidates":[{"id":"LPAR1_NB_001","generation":"generated","validation":"passed","retryCount":0,"outputUri":"local://.gpcrclaw/artifacts/campaigns/local/local-seeded-demo/candidates/LPAR1_NB_001/metrics.json","note":"passes specificity and developability gates"},{"id":"LPAR1_NB_002","generation":"generated","validation":"passed","retryCount":0,"outputUri":"local://.gpcrclaw/artifacts/campaigns/local/local-seeded-demo/candidates/LPAR1_NB_002/metrics.json","note":"highest rank score after validation"},{"id":"LPAR1_NB_004","generation":"generated","validation":"failed","retryCount":0,"outputUri":"local://.gpcrclaw/artifacts/campaigns/local/local-seeded-demo/candidates/LPAR1_NB_004/metrics.json","note":"failed missing stability evidence"},{"id":"LPAR1_NB_006","generation":"regenerated","validation":"passed","retryCount":1,"outputUri":"local://.gpcrclaw/artifacts/campaigns/local/local-seeded-demo/candidates/LPAR1_NB_006/metrics.json","note":"replacement candidate from retry wave"}],"finalReturnedResult":[{"rank":1,"id":"LPAR1_NB_002","interfaceScore":0.863,"specificityMargin":0.4,"developabilityScore":0.842,"rankScore":0.7017},{"rank":2,"id":"LPAR1_NB_001","interfaceScore":0.817,"specificityMargin":0.363,"developabilityScore":0.767,"rankScore":0.649},{"rank":3,"id":"LPAR1_NB_003","interfaceScore":0.792,"specificityMargin":0.311,"developabilityScore":0.751,"rankScore":0.618}]},"campaignRuns":{"root":"/var/task/.gpcrclaw/campaign-orchestrator/runs","runs":[]},"cloud":{"projectId":"build-wgemini26sfo-2005","region":"us-central1","builds":{"rfantibody":{"ok":false,"error":"spawn gcloud ENOENT"},"esmfold2":{"ok":false,"error":"spawn gcloud ENOENT"}},"images":[],"jobs":[],"launches":[]},"limitations":["Computational research-support output only.","Live cloud jobs are research artifacts and must not be interpreted as clinical validation.","No clinical or therapeutic conclusion is implied."]}